Australian gynencologist Dr. William McBride, who revealed a link between the anti-depression drug imipramine and?
CV Doctor seated
CV Doctor speaking
IN: "I've come...."
ENDS: "...months of pregnancy".
MACBRIDE: "I've come to the conclusion that the drug imipramine can babies to be born without arms."
REPORTER: "How many cases of these have you found in the city?"
MCBRIDE: "I have definite proof in three children that their mothers took imipramine during early pregnancy. Another three or four were out a long time. Well, we can't prove at present that the mothers did take imipramine but we suspect it from the description of the tablet."
REPORTER: "From your findings, what effect does this drug have on young children?"
MCBRIDE: "Well, these pills cause the child to be born without arms or very rudimentary arms".
REPORTER: "This has all the makings of a thalidomide tragedy. Is it as bad as that?"
MCBRIDE: "Fortunately, I don't think it will be as wide-spread as thalidomide. This drug has a manufacturer's warning that it shouldn't be taken during early pregnancy. Unfortunately, as I pointed out now the manufacturer's warning is put on a separate piece of paper and not on the bottle."
REPORTER: "This is the bottle?"
MCBRIDE. "Yes, this is the drug. So, these small tablet, if taken in early pregnancy, can cause a child to be born without arms. Now, the manufacturer's warning is put on a piece of paper which is in the box but this piece of paper is usually discarded by the dispensing chemist. He puts his label over the top of the label. Unfortunately the label on the bottle by the manufacture doesn't carry the warning that it shouldn't be used in early pregnancy and I feel that this is a great danger. I would like to see a distinctive cap with anything we think could be suspected during early pregnancy -- have a red cap with some warning message or a cap even if it would require a larger bottle: larger top. But I think there should be something so that women, if pregnant. would br???warned that she shouldn't take that tablet during pregnancy
Unfortunately, women don't know that they're pregnant the very earliest until they're about three weeks pregnant and very often until they're about two months pregnant. Of course, the arms form within the first two months of pregnancy.
Initials SGM/1255 SGM/1300
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Background: Australian gynencologist Dr. William McBride, who revealed a link between the anti-depression drug imipramine and deformed children is Sydney on Friday (March 3), is a recognised expert in the field. For, in 1961, it was Dr. McBride who discovered that deformed babies throughout the world had been damaged by the drug thalidomide during their mother's pregnancies.
Imipramine, taken by women in the early stages of pregnancy, Dr. McBride says, causes children to be born without arms -- or with rudimentary, defor??? limbs instead of arms. A manufacturer's warning that the drug must not be taken during the early stages of pregnancy -- when the foetus forms its limbs -- is supplied with the drug. BUT the warning is printed on a separate piece of paper -- usually discarded by the dispensing chemist, said Dr. McBride.
This film shown an interview with Dr. McBride, in which he revealed the potential damaging effects of the drug and called for stricter dispensing methods.
SYNOPSIS: Australian gynaecologist Dr. William McBride, who originally discovered that the drug thalidomide caused children to be born several deformed, revealed on Friday similar damaging effects in the anti-depressant drug imipramine.